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Suboptimal Biological Sampling as a Probable Cause of False-Negative COVID-19 Diagnostic Test Results.
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- Author(s): Kinloch, Natalie N (); Ritchie, Gordon (); Brumme, Chanson J (); Dong, Winnie (); Dong, Weiyan (); Lawson, Tanya (); Jones, R Brad (); Montaner, Julio S G (); Leung, Victor (); Romney, Marc G (); Stefanovic, Aleksandra (); Matic, Nancy (); Lowe, Christopher F (); Brumme, Zabrina L ()
- Source:
Journal of Infectious Diseases. 9/15/2020, Vol. 222 Issue 6, p899-902. 4p.
- Additional Information
- Subject Terms:
- Abstract:
False-negative severe acute respiratory syndrome coronavirus 2 test results can negatively impact the clinical and public health response to coronavirus disease 2019 (COVID-19). We used droplet digital polymerase chain reaction (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (ie, suspected false-negative test results) compared with a representative pool of 87 specimens submitted for COVID-19 testing. Our results support suboptimal biological sampling as a contributor to false-negative COVID-19 test results and underscore the importance of proper training and technique in the collection of nasopharyngeal specimens. [ABSTRACT FROM AUTHOR]
