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Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics.
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- Author(s): Wang, Wenjun (); Liu, Xiaoqing (); Wu, Sipei (); Chen, Sibei (); Li, Yimin (); Nong, Lingbo (); Lie, Puyi (); Huang, Liyan (); Cheng, Linling (); Lin, Yongping (); He, Jianxing ()
- Source:
Journal of Infectious Diseases. Nov2020, Vol. 222 Issue 9, p1444-1451. 8p.
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- Abstract:
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19. [ABSTRACT FROM AUTHOR]
