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Male Sex, Severe Obesity, Older Age, and Chronic Kidney Disease Are Associated With COVID-19 Severity and Mortality in New York City.

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      To the Editor: The pathophysiology of the acute respiratory syndrome in the setting of coronavirus disease 2019 (COVID-19) is not yet fully understood.[1] Differences in severity and fatality outcomes according to patient's sex have been noted across multiple early pandemic outbreak areas, such as China[2] and Italy.[3] Studies performed in the United States have examined predictors of mortality and severity; however, they included a few hundred patients[4] or were focused on time periods early in the COVID-19 outbreak, and confounders were not properly addressed with multivariate analyses.[5] SP , sp [6] Here we assess differences in COVID-19 severity between male and female patients while accounting for a large number of demographic and clinical covariates in New York City by investigating both initial presentation and mortality among hospitalized patients with COVID-19. These results add to the conversation about predictors of worse outcomes in COVID-19 patients, and point at male patients, as well as those who are older, those who are severely obese, and those with comorbidities as those likely at greatest risk of COVID-19 severity and fatality. 108, 2020, 154262 5 S. Richardson, J.S. Hirsch, M. Narasimhan, Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. [Extracted from the article]