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Academic Journal

Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries

  • Source: In Journal of the American Academy of Dermatology August 2020 83(2):486-492

  • Abstract: Background Increasing evidence suggests pernio-like lesions are cutaneous manifestations of coronavirus infectious disease 2019 (COVID-19).Methods An international dermatology registry was circulated to health care providers worldwide through the American Academy of Dermatology, International League of Dermatologic Societies, and other ... Results We documented 505 patients with dermatologic manifestations associated with COVID-19, including 318 (63%) with pernio-like lesions. Patients with pernio-like lesions were generally young ... Limitations A case series cannot estimate population-level incidence or prevalence. In addition, there may be confirmation bias in reporting. We cannot exclude an epiphenomenon.Conclusions Pernio-like skin changes of the feet and hands, without another explanation, may suggest COVID-19 infection and should prompt confirmatory testing.

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Academic Journal

National Psoriasis Foundation COVID-19 Task Force Guidance for Management of Psoriatic Disease During the Pandemic: Version 1

  • Source: In Journal of the American Academy of Dermatology December 2020 83(6):1704-1716

  • Abstract: Objective To provide guidance about management of psoriatic disease during the coronavirus disease 2019 (COVID-19) pandemic.Results The TF approved 22 guidance statements. The average of the votes was within the category of agreement for all statements. All guidance statements proposed were ... Limitations The evidence behind many guidance statements is limited in quality.Conclusion These statements provide guidance for the management of patients with psoriatic disease on topics ranging from how the disease and its treatments impact

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Academic Journal

Antecedent immunosuppressive therapy for immune-mediated inflammatory diseases in the setting of a COVID-19 outbreak

  • Source: In Journal of the American Academy of Dermatology December 2020 83(6):1696-1703

  • Abstract: Background Finite clinical data and understanding of COVID-19 immunopathology has led to limited, opinion-based recommendations for the management of patients with ... Methods We conducted a retrospective cohort analysis of Henry Ford Health System patients tested for COVID-19 between February 1 and April 18, 2020, treated ... Results Of 213 patients with IMID, 36.2% tested positive for COVID-19, and they had no greater odds of being hospitalized or requiring ventilation ... Limitations A single-center study somewhat limits the generalization to community-based settings. Only patients tested for COVID-19 were analyzed.Conclusion IS therapies for IMIDs are not associated with a significantly greater risk of SARS-CoV-2 or severe sequelae when controlling for ...

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Academic Journal

Hydroxychloroquine effects on psoriasis: A systematic review and a cautionary note for COVID-19 treatment

  • Source: In Journal of the American Academy of Dermatology August 2020 83(2):579-586

  • Abstract: Background While evidence suggests that hydroxychloroquine (HCQ) may decrease the viral load in patients with a COVID-19 infection, a number of ... Methods Embase and MEDLINE were comprehensively searched for original studies examining adverse effects of HCQ treatment related to psoriasis. Participant demographics and details of HCQ ... Results Women accounted for a significantly larger number of cases of psoriasis compared with men and unreported sex (14 [77.8%] vs 2 [11.1%] vs 2 [11.1%], respectively). In addition, 50% (n = 9) of ... Conclusion HCQ treatment may result in induction, exacerbation, or relapse of psoriasis. Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are ...

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Academic Journal

Mucocutaneous Disease and Related Clinical Characteristics in Hospitalized Children and Adolescents with COVID-19 and MIS-C

  • Source: In Journal of the American Academy of Dermatology January 2020

  • Abstract: Background Little is known about mucocutaneous disease in acutely-ill children and adolescents with COVID-19 and MIS-C.Methods Descriptive cohort study of prospectively and consecutively hospitalized eligible patients between May 11, 2020 and June 5, 2020.Results In COVID-19 patients, 4/12 (33%) had rash and/or mucositis, including erythema, morbilliform pattern, and lip mucositis. In MIS-C patients, 9/19 (47%) had rash ... Limitations Small sample sizes.Conclusions Mucocutaneous disease is common among children and adolescents with COVID-19 and MIS-C. Laboratory trends observed in patients with rash may ... @@@@Capsule Summary: Little is known about the morphologic spectrum of mucocutnaeous disease and its relation to clinical course in acutely-ill children with ...

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Academic Journal

Clinical outcomes of COVID-19 in patients taking tumor necrosis factor inhibitors or methotrexate: A multicenter research network study

  • Source: In Journal of the American Academy of Dermatology

  • Abstract: Background Data on the impact of biologics and immunomodulators on coronavirus disease 2019 (COVID-19)–related outcomes remain scarce.Methods In this large comparative cohort study, real-time searches and analyses were performed on adult patients who were diagnosed with COVID-19 ... Results More than 53 million (53,511,836) unique patient records were analyzed, of which 32,076 (0.06%) had a COVID-19–related diagnosis documented starting after January 20, 2020. Two ... Limitations All TNFis may not behave similarly.Conclusion Our study suggests that patients with recent TNFi or methotrexate exposure do not have increased hospitalization or mortality compared with patients with

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Academic Journal

Guiding principles for prioritization of limited in-person dermatology appointments during the COVID-19 pandemic

  • Source: In Journal of the American Academy of Dermatology October 2020 83(4):1228-1230

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Academic Journal

Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society

  • Source: In Journal of the American Academy of Dermatology December 2020 83(6):1730-1737

  • Abstract: The recent COVID-19 pandemic has resulted in increased hand hygiene and hand cleansing awareness. To prevent virus transmission, the Centers for ...

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Academic Journal

The spectrum of COVID-19–associated dermatologic manifestations: An international registry of 716 patients from 31 countries

  • Source: In Journal of the American Academy of Dermatology October 2020 83(4):1118-1129

  • Abstract: Background Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.Methods Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.Results The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry ... Limitations We cannot estimate incidence or prevalence. Confirmation bias is possible.Conclusions This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight ...

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