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Periodical

ROC 曲线设置流式细胞术检测HLA-B27 的临界值在强直性 脊柱炎诊断和鉴别诊断中的应用.

Subjects: DIFFERENTIAL diagnosis; ANKYLOSING spondylitis; RECEIVER operating characteristic curves

  • Source: Journal of Modern Laboratory Medicine; Nov2020, Vol. 35 Issue 6, p153-155, 3p

  • Abstract: Objective To set the threshold value of HLA-B27 fluorescence detection level by using the ROC curve and evaluate its efficiency in the diagnosis and differential ... 目的 应用ROC 曲线设定诊断强直性脊柱炎(ankylosing spondylitis,AS) 的人类白细胞抗原(Human leukocyte attigen,HLA-B27)荧光临界值,评价其在AS 诊断和鉴别诊断中的效能。方法 利用流式细胞术对40 例AS 患者和169 例与AS 患者症状相近的其他关节病患者及健康对照进行HLA-B27 荧光表达强度检测,比较各组荧光值差异, 并进行ROC 曲线分析,根据Youden 指数计算出临界值,并与原设定临界值的诊断效能进行比较。结果 AS 组的荧光 检测值、阳性率和对照组比较差异均具有统计学意义(F=40.45,P < 0.05),以试剂盒给定的荧光临界值146 为临界值, ROC 曲线下面积(AUC) 为0.92,诊断AS 的敏感度、特异度、漏诊率、误诊率和准确度分别为90.00%,91.72%, 10.00%,8.28% 和91.39%,阳性预测值、阴性预测值和Youden 指数分别为72.00%,97.48% 和0.82。根据Youden 指数 确定最佳诊断临界值为151.50,其诊断敏感度、特异度、漏诊率、误诊率和准确度分别为90.00%,93.49%,10.00%,6.51% 和92.82%,阳性预测值、阴性预测值和Youden 指数分别为76.60%,97.53% 和0.83。结论 进口试剂盒设置的诊断临 界值略低,实验室可在不影响诊断敏感度的前提下调整临界值,提高诊断AS 的特异度。 [ABSTRACT ... Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be ...

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Periodical

SHOULD YOU TRY AT-HOME GENETIC TESTING?

Subjects: *DIAGNOSTIC reagents & test kits; *GENETIC counseling; *MEDICAL ethics

  • Source: Health. Jun2020, Vol. 34 Issue 5, p38-40. 2p. 1 Color Photograph.

  • Abstract: The article offers tips before the consideration of try at home genetic testing. Topics include the diagnostic medical test identifies and ...

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